Science Corner
Most edible review sites tell you "studies show" without ever linking a study. We do it differently. Every research claim on EdibleRank is backed by a specific paper. This page collects the studies we reference across the site, with plain-language summaries and direct links to the published research.
Sleep
Effects of CBN with and without CBD on sleep quality
Bonn-Miller et al. · Experimental and Clinical Psychopharmacology · 2024
Double-blind, placebo-controlled study of 321 participants with poor sleep. 20mg CBN nightly reduced nighttime awakenings and overall sleep disturbance compared to placebo. Adding CBD did not improve outcomes beyond CBN alone. No impact on daytime fatigue.
Safety and effectiveness of CBN formulations for improving sleep
Saleska, Pauli et al. · Pharmaceuticals (MDPI) · 2024
Placebo-controlled trial of over 1,000 participants testing CBN at 25mg, 50mg, and 100mg doses. All CBN groups showed significant sleep improvement compared to placebo, with no significant difference from 4mg melatonin. CBN was well tolerated with no serious side effects.
Non-psychoactive cannabinoid formulations for sleep improvement
Saleska, Bryant, D'Adamo et al. · Journal of the American Nutrition Association · 2024
Randomized controlled trial of 1,793 adults. All CBD formulations (15mg, with and without CBN) produced significant sleep improvements, though effects did not exceed those of 5mg melatonin. Favorable safety profile with only 12% reporting mild side effects.
Anxiety
CBD as a potential treatment for anxiety disorders
Blessing, Steenkamp, Manzanares, Marmar · Neurotherapeutics · 2015
Landmark review of 49 preclinical, clinical, and epidemiological studies. Found strong preclinical evidence supporting CBD for generalized anxiety disorder, panic disorder, social anxiety disorder, OCD, and PTSD. Human evidence supports anxiolytic effects but was limited to acute dosing at the time of publication.
CBD in anxiety disorders: systematic review and meta-analysis
Multiple authors · Psychiatry Research · 2024
Meta-analysis of 8 randomized controlled trials with 316 participants. Found a substantial and significant effect of CBD on anxiety symptoms with a large effect size. Authors call for larger trials but note consistent positive findings across studies.
Chronic Pain
The Health Effects of Cannabis and Cannabinoids
National Academies of Sciences, Engineering, and Medicine · National Academies Press · 2017
The most comprehensive government review of cannabis research to date. Reviewed over 10,000 studies and reached nearly 100 conclusions. Found "conclusive or substantial evidence" that cannabis is effective for treating chronic pain in adults and for chemotherapy-induced nausea. Also found moderate evidence for improving sleep in certain conditions.
Medical cannabis use and healthcare utilization among chronic pain patients
Multiple authors · PMC / Pharmaceuticals · 2025
Causal inference analysis of medical cannabis patients with chronic pain. Found that medical cannabis use was associated with a 2.0 percentage point reduction in urgent care visits, 3.2 point reduction in ER visits, and 3.5 fewer unhealthy days per month compared to non-users.
General Cannabinoid Science
Cannabis, cannabinoids and health: risks and medical benefits
Multiple authors · European Archives of Psychiatry and Clinical Neuroscience (PMC) · 2025
Comprehensive review of cannabis health effects. Confirmed that strongest therapeutic evidence exists for CBD in epilepsy, and THC for spasticity, chronic pain, and chemotherapy nausea. Noted that evidence remains inconclusive for many neuropsychiatric conditions. Highlighted the challenge of standardizing cannabinoid preparations across studies.
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